Pētījumos apliecināta sulforafānu īpaši pozitīvā iedarbība


(1) Sulforaphane (SFN): An Isothiocyanate in a Cancer Chemoprevention Paradigm, Medicines (Basel). 2015 Sep; 2(3): 141–156.Published online 2015 Jul 17. doi: 10.3390/medicines2030141

(2) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality (1,2,3,4); Am J Clin Nutr. 2011 Jul; 94(1): 240–246. Published online 2011 May 18. doi: 10.3945/ajcn.110.009340

(3) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo; Ajita V Singh 1, Dong Xiao, Karen L Lew, Rajiv Dhir, Shivendra V Singh; 2004 Jan;25(1):83-90. doi: 10.1093/carcin/bgg178. Epub 2003 Sep 26.

(4) The influence of sulforaphane on vascular health and its relevance to nutritional approaches to prevent cardiovascular disease; 2011 Mar;2(1):9-14. doi: 10.1007/s13167-011-0064-3. Epub 2011 Feb 12.; Paul C Evans (1)

(5) https://pubmed.ncbi.nlm.nih.gov/22052072/

(6) Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation; 2015;2015:407580. doi: 10.1155/2015/407580. Epub 2015 Oct 25.; Yang Bai 1, Xiaolu Wang 2, Song Zhao 3, Chunye Ma 4, Jiuwei Cui 5, Yang Zheng 42009 Nov;29(11):1851-7. doi: 10.1161/ATVBAHA.109.193375. Epub 2009 Sep 3.

(7) Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state;

(8) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes; 2017 Jun 14;9(394):eaah4477. doi: 10.1126/scitranslmed.aah4477.

(9) Sulforaphane ameliorates glucose intolerance in obese mice via the upregulation of the insulin signaling pathway; 2018 Sep 19;9(9):4695-4701. doi: 10.1039/c8fo00763b.J Clin Biochem Nutr. 2018 Jan;62(1):75-82. doi: 10.3164/jcbn.17-42. Epub 2017 Nov 3.

(10) Natural Nrf2 activators in diabetes; 2015 Aug 25;448:182-92. doi: 10.1016/j.cca.2015.07.009. Epub 2015 Jul 9.

(11) Sulforaphane treatment of autism spectrum disorder (ASD); Proc Natl Acad Sci U S A; 2014 Oct 28;111(43):15550-5. doi: 10.1073/pnas.1416940111. Epub 2014 Oct 13.

(12) Daily intake of broccoli sprouts normalizes bowel habits in human healthy subjects

(13) Effects of sulforaphane and vitamin E on cognitive disorder and oxidative damage in lead-exposed mice hippocampus at lactation; J Trace Elem Med Biol. 2017 Dec;44:88-92. doi: 10.1016/j.jtemb.2017.06.004. Epub 2017 Jun 15.

(14) Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats; Int Immunopharmacol. 2017 Apr;45:74-78. doi: 10.1016/j.intimp.2017.01.034. Epub 2017 Feb 10.

(15)  Sulforaphane activates the cerebral vascular Nrf2-ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage; Brain Res . 2016 Dec 15;1653:1-7. doi: 10.1016/j.brainres.2016.09.035. Epub 2016 Sep 28.

(16)  Protein oxidation and aging. Science. 1992 Aug 28;257(5074):1220-4. doi: 10.1126/science.1355616.

(17) Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27; J Biol Chem. 2010 Nov 12;285(46):35528-36. doi: 10.1074/jbc.M110.152686. Epub 2010 Sep 10.

(18) Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane; J Agric Food Chem. 2006 Mar 22;54(6):2069-76. doi: 10.1021/jf0525277.

(19) Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system; Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 7094–7099.; Medical Sciences;

(20) Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene; J Biochem Mol Toxicol. Jan-Feb 2009;23(1):18-28. doi: 10.1002/jbt.20259.

(21) Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene;Biomed Pharmacother. 2011 Feb;65(1):9-16. doi: 10.1016/j.biopha.2010.08.009. Epub 2010 Sep 24.

(22) Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells; Carcinogenesis. 2005 Dec;26(12):2138-48. doi: 10.1093/carcin/bgi185. Epub 2005 Jul 20.

(23) Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice; Diabetes. 2012 Dec;61(12):3208-18. doi: 10.2337/db11-1716. Epub 2012 Aug 30.

(24) Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells; Int J Oncol. 2002 Mar;20(3):631-6. doi: 10.3892/ijo.20.3.631.

(25) Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation; Oxid Med Cell Longev. 2012;2012:821936. doi: 10.1155/2012/821936. Epub 2012 Sep 23.(26) Notch activation is dispensable for D, L-sulforaphane-mediated inhibition of human prostate cancer cell migration; PLoS One. 2012;7(9):e44957. doi: 10.1371/journal.pone.0044957. Epub 2012 Sep 7.

(27) Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells; Carcinogenesis. 2006 Apr;27(4):811-9. doi: 10.1093/carcin/bgi265. Epub 2005 Nov 9.(28) https://pubmed.ncbi.nlm.nih.gov/26841240/

(29) Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice; Diabetes 2017 May; 66(5): 1222-1236.

(30) Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality (1,2,3,4)

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